optimization

Ahmed Youssef Ragab Radwan

Visiting Student (former), Information Science Lab
Visiting student at the Information Science Lab, in the Electrical Engineering Department, CEMSE, King Abdullah University of Science and Technology (KAUST)

Estimating the expected information gain in Bayesian optimal experimental design

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B9 L2 H1

Optimal experimental design for parameter estimation is a fast-growing area of research. Let us consider the experimental goal to be the inference of some attributes of a complex system using measurement data of some chosen system responses, and the optimal designs are those that maximize the value of measurement data. The value of data is quantified by the expected information gain utility, which measures the informativeness of an experiment. Often, a mathematical model is used that approximates the relationship between the system responses and the model parameters acting as proxies for the attributes of interest.

Quantitative understanding of transcription factor regulation at network- and molecular-levels through optimization and deep learning

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KAUST

Transcription factors are an important family of proteins that control the transcription rate from DNAs to messenger RNAs through the binding to specific DNA sequences. Transcription factor regulation is thus fundamental to understanding not only the system-level behaviors of gene regulatory networks, but also the molecular mechanisms underpinning endogenous gene regulation. In this talk, I will introduce our efforts on developing novel optimization and deep learning methods to quantitatively understanding transcription factor regulation at network- and molecular-levels. Specifically, I will talk about how we estimate the kinetic parameters from sparse time-series readout of gene circuit models, and how we model the relationship between the transcription factor binding sites and their binding affinities.

Powering the bottom line

1 min read ·
A risk-based optimization scheme boosts confidence and profitability for future mixed-technology power plants.

Accelerating the grapevine effect

1 min read ·
By looking at classical gossip algorithms from a novel perspective, KAUST Professor Peter Richtarik has found a way to significantly speed up gossip-based information sharing, and in the process, he discovered new applications for this efficient mathematical approach. Gossip involves the sharing of information between individuals in a network and can be applied mathematically in both human social networks and data networks, such as distributed sensors. “A network is a collection of nodes, each connected to other nodes via links,” explains Richtarik. “In social networks, for instance

KAUST Professor Peter Richtárik wins Distinguished Speaker Award

1 min read ·
Peter Richtárik, KAUST professor of computer science, recently received a Distinguished Speaker Award at the Sixth International Conference on Continuous Optimization (ICCOPT 2019) held in Berlin from August 3 to 8. ICCOPT 2019 was organized by the Mathematical Optimization Society and was hosted this year by the Weierstrass Institute for Applied Analysis and Stochastics.

Samuel Horváth

Ph.D. Student, Statistics
Samuel Horváth is a Ph.D. candidate at Visual Computing Center (VCC) in King Abdullah University of Science and Technology (KAUST), studying under the supervision of Professor Peter Richtarik in his research group. Education and Early Career Samuel studied Financial Mathematics at Comenius University in Bratislava, Slovakia and obtained his bachelor in 2017. Then, he joined the MS/PhD program in Statistics and Optimization at KAUST in 2017. In 2018, he had an internship (Machine Learning Intern) at Exponea for 3 months. Research Interest His research interest include Optimization for Big Data

Peter Richtarik

Professor, Computer Science
Professor Richtárik specializes in big data optimization and machine learning. He is known for his work on randomized coordinate descent algorithms, stochastic gradient descent and federated learning.